Create or join a Head-to-Head League and square off weekly against other managers. Each manager sets their lineup based on league requirements and is matchup up weekly with an opponent based on the league's schedule. Whoever ends up with the most fantasy points—based on your league settings—wins the game. Weekly results are then tallied into an overall record.

Depending upon the specific settings, your league might use a playoff system to determine a champion. In non-playoff leagues, the team with the best winning percentage wins the championship. In playoff leagues, the top teams have an elimination tournament to determine a winner.

Join a Points League and simply set your goal on being the highest scorer. Set a weekly lineup based on league requirements and hope your players collect more fantasy points than anyone else's. Points are tallied throughout the football season, and the team with the highest total at the end of the year wins the league championship.