To prevent spam, many ISPs block external outgoing mail servers configured for port 25 (AT&T, Charter, COX, Earthlink, Flashnet, MediaOne, Mindspring, MSN, NetZero, Optimum Online, Sympatico, and Verizon are known to block this port). You can check to see if your ISP blocks external SMTP servers by running a simple test:
telnet://smtp.bizmail.yahoo.com:25
If the port isn't being blocked, you'll receive a response starting with a "220." If you do not receive a 220 response, your ISP is blocking outgoing mail servers, and you will need to change the SMTP port from 25 to 465 (recommended) or 587. Before doing this, make sure Microsoft Outlook checks SMTP authentication:
If you continue to have problems, please contact your ISP.